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KMID : 1123920080220010148
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Korean Journal of Oriental Physiology and Pathology
2008 Volume.22 No. 1 p.148 ~ p.154
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Study on the Vasorelaxant Mechanism of the Butanol Extract of Euonymus alatus
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Li Xiang
Kang Dae-Gil
Lee Jun-Kyoung
Choi Deok-Ho
Lee Gye-Bok
Yum Ki-Bok
Lee Ho-Sub
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Abstract
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The butanol extract of Euonymus alatus (BEA) induced dose-dependent relaxation of phenylephrine-precontracted aorta, which was abolished by removal of functional endothelium. Pre-treatment of the endothelium-intact aortic tissues with (L-NAME), and 1 H-[1,2,4]-oxadiazole- []-quinoxalin-1-one (ODQ) inhibited the relaxation induced by BEA, respectively. BEA-induced vascular relaxation was not blocked by glibenclamide, tetraethylammonium (TEA), indomethacin, atropine, propranolol, verapamil, and diltiazem, respectively. Moreover, BEA inhibits phenylephrine-induced vascular constriction in a dose-dependent manner. These results suggest that BEA relaxes vascular smooth muscle via endothelium-dependent nitric oxide/cGMP signaling.
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KEYWORD
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butanol extracts of Euonymus alatus (BEA), aortic tissues, endothelium, nitric oxide/cGMP signaling, relaxation
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